Effect of brain prolactin-releasing peptides (PrRP) on hypothalamic gonadotrophin releasing hormone

• 作 者: YiFENG[1]XiaoYAO[2]Jun-weiHAO[3]Bo-yingCHEN[3]
• 机 构: Department of Neurobiology and Integrative Medicine, Shanghai Medical College of Fudan University, S
• 出 处: 中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
• 发表日期: 2007年期

　　Prolactin-releasing peptide (PrRP) was isolated and identified as an endogenous hypothalamic ligand for the GPR10 (G protein-coupled receptor 10).The anatomical distribution of PrRP-immunoreactive (PrRP-ir) neurons in the central nervous system supports the hypothesis that PrRP could be involved in the regulation of hypothalamus-pituitaryovary axis (HPOA).The aim of this study was to examine the action of brain PrRP and to investigate the mechanism of PrRPs effect by measuring of hypothalamic gonadotropin releasing hormone (GnRH) and pituitary luteinizing hormone (LH) releasing in ovariectomized rats in vitro.In the present experiment,PrRP-31 could inhibit the super-release of GnRH directly but didnt affect LH releasing.And we have shown for the first time the co-localization of GnRH and GPR10 in hypothalamic preoptic area (POA),which might provide the direct morphological evidence that PrRP might be partly responsible for the regulation of GnRH release via its receptor3/4GPR 10 in rat brain.These results suggested that PrRP,as a regulatory neuropeptide,regulates the gonadotrophin secretion acting via a hypothalamic mechanism involving the release of GnRH.