Differential roles of Mre11 nuclease in DNA damage responses in the budding yeast and mammalian cell

来源 :The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern | 被引量 : 0次 | 上传用户：carboy123

【摘要】

：

　　Homologous recombination (HR) repairs double-strand breaks (DSBs) generated by radiotherapy and anti-cancer agents such as camptothecin and cisplatin.HR is

【作者】

：

ShunichiTakeda;

【机构】

：

Kyoto University

【出处】

：

The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern

【发表日期】

：

2015年期

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　　Homologous recombination (HR) repairs double-strand breaks (DSBs) generated by radiotherapy and anti-cancer agents such as camptothecin and cisplatin.HR is initiated by DSB strand resection, where DSBs are processed by nucleases to generate 3'single-strand DNA (3'ssDNA), followed by the polymerization of Rad51 recombinase on the 3'ssDNA.

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Differential roles of Mre11 nuclease in DNA damage responses in the budding yeast and mammalian cell

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