[目的]探讨苯肾上腺素预处理对放射损伤早期大鼠颌下腺p-JNK 表达的影响.[方法]取Wistar 大鼠27 只，随机分为空白对照组、单纯照射组和苯肾上腺素预处理组，预处理组大鼠照射前半小时腹腔注射苯肾上腺素5mg/kg.应用直线加速器给予大鼠颌下腺区域20Gy X 线照射，照射后7 天取大鼠颌下腺组织，应用免疫组织化学方法检测各组大鼠颌下腺p-JNK 的定位及表达；应用免疫印迹法(Western
患者男,76 岁,因左颊部粘膜肿大积血半天入院,患者昨晚进食人参汤后即出现腹痛腹泻,后发现左颊粘膜肿大,伴出血,无疼痛.口腔专科检查:双侧颌面部基本对称,口腔卫生一般,左颊粘膜见一3.0cm*2.0cm 肿大突起,紫红色,边界尚轻,无明显疼痛,局部渗血,活动度一般.左舌尖部件紫红色肿大突起,表面糜烂,轻度渗血,舌活动自如,无麻木,咬合关系基本正常.其余口腔粘膜未见明显溃烂及出血点.全身检查:双侧小
Aim To evaluate the correlation between non-alcoholic fatty liver disease and bone mineral density in Northwest Chinese adults.Methods A total of 215 patients (93males and 122 postmenopausal females)
Currently,major concerns about the safety and efficacy of RNA interference(RNAi)-based bone anabolic strategies still exist because of the lack of direct osteoblast-specific delivery systems for osteo
Objectives This article reported an untypical patient with part of the characteristics of osteogenesis imperfecta type V whose symptoms were however quite mild and exhibited a tendency of self-relief.
目的 脂肪细胞和成骨细胞的分化存在相互制约的平衡关系.有研究表明miRNA在间充质干细胞(mesenchymal stem cells,MSCs)向脂肪细胞及成骨细胞分化过程中起到重要作用.本研究以miR-20a为对象探讨其对脂肪细胞分化的作用,预测并鉴定其靶基因,阐明miR-20a促进脂肪细胞分化的机制.方法 1.分离并培养小鼠骨髓MSCs,采用基因芯片技术和qRT-PCR检测miRNA在诱导成
目的 研究Vaspin对小鼠成骨前体细胞MC3T3-E1细胞系成骨分化的影响及其具体机制,为骨质疏松预防和治疗提供新靶点.方法 1.用不同浓度Vaspin或联合β-GP干预MC3T3-E1后检测成骨标志物表达变化,以明确Vaspin对MC3T3-E1成骨分化的影响;2.通过microarray技术筛选可能参与的miRNA,并通过qRT-PCR验证芯片结果;3.转染miRNA mimics或inhi
目的 骨质疏松性椎体压缩骨折(osteoporotic vertebral compression fratures,OVCFs)是老年性骨质疏松症常见且较严重的并发症.对于OVCFs后导致的部分患者腰背部持续疼痛,经皮椎体成形术(percutaneous vertebroplasty,PVP)和经皮椎体后凸成形术(percutaneous kyphoplasty,PKP)已是目前普遍应用的止痛效
Aims Fibrodysplasia ossicans progressiva (FOP;OMIM ＃135100) is a rare and severely disabling genetic disease characterized by progressive and cumulative heterotopic ossi R206H) in activin receptor typ
Objective To investigate the early changes in serum calcium (Ca) and phosphorus (P) content and bone mineral density of the femoral head,following steroid administration and to clarify the timing of t