Effects of simvastatin on hypertrophy and protein kinase B expression of rat cardiomyocytes

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  Objective To study the effects of simvastatin on the serum-induced hypertrophy of cultured rat cardiomyocytes, and to investigate the role of phosphoinositide 3-kinase (PI3K) /protein kinase B (PKB) pathway in the related mechanism.Methods Cardiomyocytes were derived from neonatal Sprague-Dawley (SD) rat.
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