Involvement of PI3KAktFoxO3a and PKACREB signaling pathways in protective effect of fluoxetine again

• 作 者: ZENG Bing-qing WANG Hai-tao XU Jiang-ping
• 机 构: GroupofNeuropharmacogyandNewDrugDiscovery,SchoolofPharmaceuticalSciences,SourthernMedicalUniversity,
• 出 处: 第十七届全国神经精神药理学学术会议
• 发表日期: 2016年5期
• 关键词: depression FoxO3a CREB corticosterone

　　OBJECTIVE Phosphatidylinositol-3-kinase/protein kinase B/forkhead box O3a(PI3K/Akt/FoxO3a)signaling pathway plays a critical role in mediating neuronal cell survival.And it has been proved that antidepressants can protect neuron from brain insults.