Salvia Miltiorrhiza inhibits liver fibrosis via promoting functions of hepatic natural killer cells

来源 :中华医学会第十七次全国病毒性肝炎及肝病学术会议暨2015年中华医学会感染病学分会年会、中华医学会肝病学分会年会 | 被引量 : 0次 | 上传用户：dlzshy

【摘要】

：

Background and aim: Salvia miltiorrhiza(SM)is a Chinese herbal medicine,which is widely used for liver injury,renal interstitial fibrosis,cardiovascular diseases and so on.In this study,the extractum

【作者】

：

Yuan Peng Yanyan Tao Kai Huang Tianhui Zheng Tao Yang Chenghai Liu

【机构】

：

Institute of Liver Diseases,Shuguang Hospital affiliated to Shanghai University of Traditional Chine

【出处】

：

中华医学会第十七次全国病毒性肝炎及肝病学术会议暨2015年中华医学会感染病学分会年会、中华医学会肝病学分会年会

【发表日期】

：

2015年3期

【关键词】

：

Salvia miltiorrhiza (SM) natural killer (NK) cells hepatic stellate cell (HSC) c

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Background and aim: Salvia miltiorrhiza(SM)is a Chinese herbal medicine,which is widely used for liver injury,renal interstitial fibrosis,cardiovascular diseases and so on.In this study,the extractum of SM was previously obtained from its raw medical material according to the procedures of Chinese pharmacopoeia,and the identification and quantitation of the main bioactive compounds were detected by HPLC/MS.We aim to investigate the effects of SM extractum on inhibiting liver fibrosis via promoting functions of hepatic natural killer(NK)cells in vivo and in vitro.

其他文献

Risk of incident coronary artery disease in patients with chronic hepatitis B

Background and Aim: Patients with chronic hepatitis B usually present metabolic abnormalities and hemodynamic changes,which are associated with the development of coronary artery disease(CAD).However,

会议

chronic hepatitis Bcoronary artery diseaserisk factor

拉米夫定、恩替卡韦对乙型肝炎表面抗原阳性乳腺癌患者化疗中乙肝病毒再激活的防治效果及经济效益分析

会议

乳腺癌化疗乙肝病毒再激活拉米夫定恩替卡韦

Fibroscan对慢性乙型肝炎早期肝纤维化诊断价值研究

目的：肝纤维化是慢性乙型肝炎主要的病理改变，早期肝纤维化影像学和生化指标无特异性改变，往往不易获得诊断。尽管肝脏组织学检查是诊断早期肝纤维化最好的方法，但是由于其有创性及潜在的风险，不宜用于常规检查。寻找一种可靠、经济、快效、方便无创肝纤维化诊断方法，用于检测慢性乙肝早期肝纤维化具有重要意义。本研究旨在探讨Fibroscan(瞬时肝脏弹性成像技术)对慢性乙型肝炎早期肝纤维化诊断价值。

会议

慢性乙型肝炎肝纤维化肝脏硬度值Fibroscan

肝脾调补方对日本血吸虫病所致肝损伤保护作用机制研究

目的：通过观察中药肝脾调补方对日本血吸虫病肝损伤模型小鼠肝功能指标及有关细胞因子表达水平的影响,研究其对小鼠日本血吸虫病肝损伤的保护作用及其机制。方法：72只昆明小鼠随机分为A正常组、B模型组、C肝脾调补方组,用日本血吸虫尾蚴皮肤敷贴法感染小鼠,构建日本血吸虫病肝损伤模型,于8W、12W分别随机抽取10只小鼠,自小鼠眼眶静脉丛取血和刨杀留取肝脏标本,观察其肝脏组织形态,ELISA检测ALT、AST

会议

日本血吸虫病肝损伤肝脾调补方

The mechanism of HCV core protein manipulating human blood-derived monocytes differentiating to macr

Background: Hepatitis C virus(HCV)core protein as a structural protein can trigger inflammatory cell activation and modulate immune responses,although the mechanisms that mediate these effects are not

会议

regulationdifferentiation

我国乙型肝炎病毒复制/感染模型研究及应用进展

目前，乙型肝炎及其相关的终末期肝病，如肝硬化和肝癌的发病机制仍不清楚，现有的抗病毒药物如干扰素和核苷类似物的治疗效果仍不理想。解决上述基础理论问题和新药研发均离不开合适的乙型肝炎病毒(HBV)感染模型。然而，我国在该领域的研究与国际研究水平以及国内实际需求相比差距很大，成为制约我国乙肝防治以及实现传染病防治重大科技专项总体目标的瓶颈问题。

会议

乙肝病毒细胞动物模型

Inhibitory Effect of miR-125b on HCV Core Protein-induced TLR2/MyD88signaling in THP-1cells

OBJECTIVES: Macrophages/Monocytes have been shown to be important immune cells mediating both innate and adaptive immunity in hepatitis C virus(HCV)infected patients.Many anti-pathogen pathways,includ

会议

hepatitis C virus (HCV)MiR-125bmonocytesToll like receptor 2 (TLR2)

TNFα induce IP3R1 expression through TNFR1/PC-PLC/PKCα/ERK1/2 signaling pathways in human mesangial

Objectives To elucidate the molecular mechanisms regarding the decreased glomerular filtration rate when hepatorenal syndrome occurs(HRS),relationship between PLC,protein kinase C(PKCα),MAPK kinase an

会议

HRSTNFαIP3R1PKCαERK

丹参多酚酸盐保护肝细胞线粒体抗肝损伤的作用

目的观察丹参多酚酸盐(salvianolate)保护肝细胞线粒体抗大鼠肝损伤的作用.方法 55只雄性 Wistar大鼠随机分为正常组和造模组,造模组首次予皮下注射CCl4原液(3mL·kg-1)6小时后随机分为模型组、高剂量组、低剂量组和N-乙酰-L半胱氨酸(NAC)组.模型组、高、低剂量组和NAC组予皮下注射50％CCl4 2ml·kg-1,3日1次,连续2周；正常组予相同时间皮下注射等剂量橄

会议

丹参多酚酸盐四氯化碳肝损伤线粒体

Upregulated expression of SENP3 plays an important role in lipid metabolism pathway in non-alcoholic

Background: Non-alcoholic fatty liver disease(NAFLD),ranging from nonalcoholic fatty Liver(NAFL)to progressive non-alcoholic steatohepatitis(NASH)and fibrosis,has become an increasingly common healthy

会议

non-alcoholic fatty liver diseaseSENP3lipid metabolism

Salvia Miltiorrhiza inhibits liver fibrosis via promoting functions of hepatic natural killer cells

其他学术论文