论文部分内容阅读
Behavioral tagging process that in analogy to the synaptic tagging and capture process, recently has been proposed as a mechanism of long-term memory (LTM) formation in intertwining memory events.However, the mechanical substrate for behavioral tagging remains unclear.Here, we report that novel, but not familiar objects exploration facilitates hippocampal CA1.long-term depression (LTD) in freely moving rats.Blocking LTD by the specific NR2B antagonist Ro25-6981 or synthetic peptide Tat-GluR23Y that interferes with the endocytosis of postsynaptic AMPA receptors, prevents the learning phenomenon of novelty acquisition, suggesting that hippocampal LTD is required for novelty acquisition.In addition, novelty exploration promotes the conversion of short-term memory (STM) into LTM through the mechanism of behavioral tagging process as previous reports in inhibitory avoidance (IA) paradigm.Either Ro25-6981 or Tat-GluR23Y peptide can prevent the conversion of STM into LTM promoted by novelty exploration.Moreover, pharmacologically facilitating the induction of hippocampal LTD by the glutamate transporter inhibitor DL-TBOA mimics the behavioral effects of novelty exploration by promoting the conversion of STM into LTM.Taken together, our findings for the first time suggest that LTD is required for novelty acquisition and may serve as a mechanical substrate for behavioral tagging process.