Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer

• 作 者: TengLiu;ChaoWang;ZhuangLiu;
• 机 构: Functional Nano & Soft Materials Laboratory(FUNSOM)and Jiangsu Key Laboratory for Carbon-Based Funct
• 出 处: 中国化学会第29届学术年会
• 发表日期: 2014年期

　　Chemically exfoliated MoS2 nanosheets are modified with polyethylene glycol(PEG)via thiol chemistry,obtaining PEGylated MoS2(MoS2-PEG)with high stability in physiological solutions and no obvious in vitro toxicity to cells.Taking advantages of the ultra-high surface area of those 2D atomic sheets,the obtained MoS2-PEG is able to load a number of therapeutic molecules with high loading capacities by hydrophobic interactions.Using doxorubicin(DOX)as the model drug,synergistic anti-cancer effect of combined chemotherapy and photothermal therapy is observed in both in vitro and in vivo experiments with MoS2-PEG nanosheets as the multifunctional nano-platform.Our work highlights the great promise of functionalized TMDCs for the first time,another type of 2D nanomaterials sharing similar structures and properties of graphene,as novel drug carriers with multi-functionalities for cancer combination therapy,and opens a new and exciting avenue in the development of TMDCs for biomedical applications.