Dynamic Processes at Multivalent Receptor Surfaces

• 作 者: JurriaanHuskens;
• 机 构: University of Twente, MESA+ Institute for Nanotechnology, Molecular Nanofabricationgroup, P.O. Box 2
• 出 处: 中国化学会第28届学术年会
• 发表日期: 2012年期

　　Supramolecular host-guest chemistry has been well established in solution,but its use at interfaces remains limited to for example sensor development for specific guest compounds.In order to build assemblies at surfaces through supramolecular interactions for nanotechnological applications,other demands have to be met,such as larger thermodynamic and kinetic stabilities of the assemblies.For many supramolecular motifs,this inevitably leads to the use of multivalent interactions.Multivalency describes the interaction between multivalent receptors and multivalent ligands.It plays a pivotal role in biochemistry,particularly in protein-carbohydrate interactions,both in solution and at interfaces,e.g.in the infection of cells by the attachment of viruses or bacteria to cell membranes.In particular in the latter case,multivalency is often poorly understood in a quantitative sense.