The effect of telbivudine on peripheral blood CD4+ CD25+ CD127+ T cells and CD8+ CD25+ T cells in pa

• 作 者: ZhangMengjun;ZhouJijun;WangLi;LiJie;
• 机 构: Institute of Immunology PLA, Third Military Medical University, Shapingba, Chongqing,400038
• 出 处: 全军免疫学第七届学术交流会暨免疫学新进展主题论坛
• 发表日期: 2009年期

　　Objective To investigate the effect of telbivudine on peripheral blood CD4+ CD25+ CD127+ T cells and CD8+ CD25+ T cells and its significance in patients with chronic hepatitis B.Methods:Nineteen HBeAg positive chronic hepatitis B patients were recruited and received telbivudine treatment.Before and after the 3 or 6 months Of treatment,flow cytometry was used to dectect the proportion of peripheral blood Tregs.Rusults The proportion of peripheral blood Tregs in patients with CHB was significantly higher than that in healthy controls and decreased over 3 or 6 months of telbivudine treatment to a level comparable to that of the healthy controls.