The 3Rs in chemical safety assessment a vision to pioneer better science

来源 :2015毒性测试替代方法与转化毒理学(国际)学术研讨会 | 被引量 : 0次 | 上传用户：xub23

【摘要】

：

　　There are ethical, business, scientific and legislative drivers to replace, refine,and reduce the use of animals in research and testing.Across many areas o

【作者】

：

Natalie Burden

【机构】

：

NationalCentreforReduction,RefinementandReplacementofAnimalsinResearch(NC3Rs),UnitedKingdom

【出处】

：

2015毒性测试替代方法与转化毒理学(国际)学术研讨会

【发表日期】

：

2015年7期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　There are ethical, business, scientific and legislative drivers to replace, refine,and reduce the use of animals in research and testing.Across many areas of bioscience, various approaches have been developed in line with the principles of the 3Rs, which are now beginning to be applied in practice.

其他文献

High through-put alternatives to underpin category approaches and read-across of UVCBs for regulator

　　Current regulatory schemes for the notification and registration of chemicals require extensive animal testing for hazard assessment.

会议

Combining in vitro testing along with systems modeling to predict drug-induced liver injury?

　　We have developed a systems-based DILI prediction platform that integrates in vitro and in silico approaches to simulate hepatocellular homeostasis and pred

会议

Analysis of Chemical Bioactivity through In Vitro Profiling using ToxCast and Tox21 High-Throughput

　　Safety assessment of drugs and environmental chemicals relies extensively on animal testing.However, the quantity of chemicals needing assessment and challe

会议

Threshold or No Threshold: The Story of Molecular Circuitry in Cells

　　Increasingly, there is a move toward using in vitro toxicity testing for assessment of human health risk of chemicals.As with in vivo toxicity testing, an i

会议

The Role of Structural Flexibility in the Modulation of Estrogen Receptor-Mediated Endocrine Disrupt

　　Estrogen receptor belongs to Type Ⅰ nuclear receptors which are largely located in the cytosol of cells in complex with heat shock proteins in the absence

会议

细胞应激损伤效应的胞内信号转导网络

会议

细胞应激损伤效应胞内

Use of in vitro test methods for product stewardship and the development of safer products

　　The use of in vitro safety test methods by the cosmetics, personal care, and household products industries in North America and Europe has progressively rep

会议

State-of-the-Art Assessment Approaches for Chemical and Product Safety

　　Approaches to toxicological hazard and risk assessment are advancing at an unprecedented rate, particularly in relation to the "3R" objective of replacement

会议

Environmental Risk Assessment Past, Present and Future

　　Unilever has a long history of assessing and managing the risk to the environment from the chemicals in our products.This talk will reflect on the scientifi

会议

组织工程技术--从临床应用到体外测试

会议

组织工程技术临床应用

The 3Rs in chemical safety assessment a vision to pioneer better science

其他学术论文