m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency

来源 :第三届数学、计算机与生命科学交叉研究青年学者论坛 | 被引量 : 0次 | 上传用户：liyongrubylian

【摘要】

：

N6-methyladenosine (m6A) has been recently identified as a conserved epitranscriptomic modification of eukaryotic mRNAs, but its features,regulatory mechanisms,

【作者】

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王秀杰

【机构】

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中国科学院遗传与发育生物学研究所

【出处】

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第三届数学、计算机与生命科学交叉研究青年学者论坛

【发表日期】

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2015年5期

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N6-methyladenosine (m6A) has been recently identified as a conserved epitranscriptomic modification of eukaryotic mRNAs, but its features,regulatory mechanisms, and functions in ceil reprogramming are largely unknown.Here, we report m6A medification profiles in the mRNA transcriptomes of four cell types with different degrees of pluripotency.Comparative analysis reveals several features of m6A, especially geneand cell-type-specific m6A mRNA rnodifications.We also show that microRNAs (miRNAs) regulate m6A modification via a sequence pairing mechanism.

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m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency

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