Induction of Cancer Cell-specific Cell Death and Alteration of Sugar Chain Synthesis Pathways by Low

来源 :2011第四届世界癌症大会 | 被引量 : 0次 | 上传用户:dong770527
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  Fucoidan is sticky fucose-rich sulfated polysaccharides derived from seaweeds such as Konbu or Mozuku.Low molecular weight fucoidan extract (LMWFE) digested by abalone glycosidases exhibited anti-invasion and antiangiogenesis effects.LMWFE is now widely used for therapy of terminal cancer patients in Japan.Recently, we found that LMWFE induced cancer cell-specific cell death, which is enhanced by concanavalin A (Con A), a lectin recognizing mannose moiety of polysaccharides.
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