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The protection of intellectual properties is essential to the competitiveness of nations and organizations, to their attractiveness for investors, to their equity for inventors and artists.While complying with the external laws and rules in the playground, each producer, agent, mediator of intellectual property and knowledge in particular has its own opinions and approaches to fine-tune their strategies to meet their goals-for profit or public good-when interacting with each other.Rapid advancement in technology,business models, government decisions and policies are three other driving determinants that together form another layer of operating scheme around the philosophy of intellectual property management.Therefore,there is a demand for optimal, balanced intellectual property systems to ensure they offer appropriate rewards to invest in innovation, while at the same time ensuring research progress is not adversely stifled and knowledge is properly diffused.This Article is about the legal and political instruments directed toward conveyance of technology in theory and in practice.Taking biomedical industry in the United States as the template for exploring transfer of technology, this papers structure examines the issue about access to healthcare resource in general and biomedical research tool in specific, explores the theories behind unfavorable effects of patenting research tools, and outlines the practices adopted by universities, business entities, and non-profit institutions in response to the counter the problem.