【摘 要】
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Epsilon toxin (ETX), a potential biological warfare agent, is produced by toxinotypes B and D of Clostridium perfringens.It can cause lethal enterotoxemia i
【出 处】
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第12届生物毒素研究及医药应用学术大会
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Epsilon toxin (ETX), a potential biological warfare agent, is produced by toxinotypes B and D of Clostridium perfringens.It can cause lethal enterotoxemia in domestic animals, mainly sheep, goats and cattle, causing serious economic losses to global animal husbandry.In this study, a novel and stable epsilon toxin mutant rETXY196E-C, obtained by a new way: simultaneous replacement of Y 196 with glutamic acid and introduction of 23 C-terminal peptides, was determined as a promising recombinant vaccine candidate against enterotoxemia.
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