【摘 要】
：
The short arm of chromosome 3 is frequently altered in human cancer of different tissue origin.Certain regions on chromosome ann 3p are defined by frequent
【机 构】
：
University of Iceland, Iceland
【出 处】
：
2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
论文部分内容阅读
The short arm of chromosome 3 is frequently altered in human cancer of different tissue origin.Certain regions on chromosome ann 3p are defined by frequent hemi-and homozygous deletions in various tumorigenic cell lines and carcinoma tissues.Also,regions at 3p have been defined by elimination in microcell hybrids parallel to increased tumourigenecity in SCID mice.We have analysed chromosome instability and several genes involved in tumour pathogenesis at 3p,such as:VHL (angiogenesis),RIITGFB (antigrowth control),CATNB (cell adhesion and transcriptional control),MLH1 (mismatch repair) and FHIT (apoptosis).
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