A safe and efficient hepatocyte-selective carrier system based on myristoylated preS1/21-47 domain o

• 作 者: QuanZhang;TijiaChen;XunSun;TaoGong;ZhirongZhang;
• 机 构: West China School of Pharmacy,Sichuan University,Chengdu,China 610041
• 出 处: 2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
• 发表日期: 2014年期

　　A safe and efficient liver targeted PEGylated liposome (PEG-Lip) based on N-terminal myristoylated preS1/21-47 (preS1/21-47myr) of hepatitis B virus was successfully developed.The study aimed to elucidate the cellular uptake mechanism of preS1/21-47myr modified PEG-Lip (preS1/21-47myr-PEG-Lip) in hepatogenic cells and the distribution behavior of preS 1/21-47myr-PEG-Lip in Vr:C D 1 (ICR) mice.The cellular uptake results showed preS1/21-47myr-PEG-Lip were effectively uptaken by hepatogenic cells (including primary hepatocytes and liver tumor cells) through a receptor-mediated endocytosis pathway compared with non-hepatogenic cells.