论文部分内容阅读
Background : The abnormal of airway structure play a key role in the pathological process of breathing-associated disease, especially in obstructive sleep apnoea-hypopnea.Obstructive sleep apnea (OSA) syndrome is a surprisingly complex and highly individualized disease, with different factors contributing toward the disease process.Many factors can induce OSA disease, such as hypertrophy uvula, adenoidectomy, tonsil caused by mechanical obstruction of the airway, airway obstruction on obesity cause of decubitus, etc, in addition, abnormal structure and function of airway is the most important factors.Imaging analysis during drug induced sleep provides a non-invasive method for detected the abnormal of airway structure.To identify obstructive plane is not only regard as the important part of diagnosis but also the operative target before cure procedure.Imaging examination, include X-ray, CT, MR, is developing rapidly, which is widely performed in hospital to diagnose the The abnormal of airway.For the more the airway three-dimensional reconstructions could simulated airway anatomy in pathological condition.Combining some clinical phenomena of patients with OSA, it seems that no close relation with OSA has been observed in sober.Compared with polysomnography (PSG), airway three-dimensional reconstructions during drug induced sleep offer the possibility of an accurate diagnosis with convenience and low-cost.Efficient and early diagnosis of obstructive sleep apnea may help prevent the development of related morbidity and mortality.In this study, we propose an imaging methodology for obstructive sleep apnoea and evaluate the effect of this method.Objective: To explore the differential diagnostic value of the airway three-dimensional reconstructions during drug induced sleep in obstructive sleep apnea.Methods: ninety nine children diagnosis obstructive sleep apnea with polysomnography were examined by the airway three-dimensional reconstructions during drug induced sleep, and the obstructive ratios of patients and normal controls were measured.The quantized results were used as gold standard , the best critical value of obstructive ratios was confirmed by receiver operating characteristic (ROC) curve.Results: The mean obstructive ratio in obstructive sleep apnea group and control group were O.06 and 1.11, reapeetively.There was significant difference of ratios between obstructive sleep apnea group and control group (P<0.001).The critical value of elasticity straining ratios coniinned by ROC curve was 0.85 for diagnosing obstructive sleep apnea.The sensitivity, specificity and accuracy were 77.0%, 89.7 % , 91.9 % , respectively.Conclusion: obstructive ratio of the airway three-dimensional reconstructions during drug induced sleep can primarily assess the obstructive sleep apnea.and it provides a new convenience diagnostic tool.Strengthened by the blinded design of most of RCT studies, this technology represents a viable alternative to PSG for confirmation of clinically suspected sleep apnea.