Up regulation of aquaporin 1, 4 and 9 expressions in brain edema after rat traumatic brain injury

• 作 者: F.YUAN;L.ZHANG;Y.CUI;L.X.XU;
• 机 构: Beijing Neurosurgical Institute, Beijing 100050, China
• 出 处: 中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
• 发表日期: 2007年期

　　Objective Aquaporins (AQPs) are a family of water-selective channels that provide a major pathway for osmotically driven water transport through cell membranes.Among AQP subtypes cloned in mammalian,only AQP 1,4 and 9 were identified in the brain.Emerging evidence suggests that brain AQPs play important roles for the dynamic regulation of brain water homeostasis and may be correlated with edema formation of the brain.The purpose of this work is to study the exoression of AQP 1,4 and 9 in rat brain and their roles in brain edema after traumatic brain injury (TBI).