【摘 要】
：
An important group of anticancer drugs are methylating and chloroethylating agents that are being used in first line therapy of gliomas and malignant melano
【机 构】
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Department of Toxicology University of Mainz Germany
【出 处】
：
BIT Life Sciences' 1st Annual World Cancer Congess-2008(
论文部分内容阅读
An important group of anticancer drugs are methylating and chloroethylating agents that are being used in first line therapy of gliomas and malignant melanomas.These agents induce a dozen of DNA lesions, some of them have been identified to be carcinogenic, genotoxic and cytotoxic.In MGMT lacking cells O6-methylguanine (O6MeG) and O6-chloroethylguanine (O6ChlG) are the major trigger of genotoxicity and apoptosis.In the case of O6MeG lesions, this requires MSH2/MSH6 dependent mismatch repair.O6MeG triggered cell death is regulated in a cell type specific manner, utilizing both the mitochondrial and the death receptor pathway.
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