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We have previously reported that Shih Quan Da Bu Tang ameliorated amyloid burden in Alzheimer model mice by activating microglia.However, it needs huge money and time to make it available as a medicine.Moreover, it is now known that Alzheimer pathology starts 20 years prior to onset of dementia,suggesting that prevention is more important.However, we cannot apply any medicine including the traditional chinese medicine for prevention because of the medical care insurance in Japan.Accordingly,the functional food (supplement) is becoming more and more popular.Since Japanese Government (Consumer Affairs Agency) approved the function indication on the functional food in April, 2015, full of industry people gathered at a recent trade fair of supplement in Tokyo.There are numerous supplement reported to be good for dementia.However, the evidence level is not yet high enough.Most of intervention studies turned out negative, while many cohort studies were positive.This discrepancy is probably because that exposure time is short and the exposing factor is mostly single in the intervention study, while it is longer and multiple in the cohort study.It is also possible that intervention after onset of dementia is too late.Here I will talk about feruric acid, curcumin, docosahexanoic acid (DHA)and huperzine A for prevention and treatment of Alzheimer's disease.