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Objective: Hepatitis B virus reactivation(HBVr)is a known complication of immunosuppressive therapy in transplantation,autoimmune disease,chemotherapy.The risk of developing HBVr-related liver failure is not clear.This study describes the risk factors of HBVr-related liver failure.Results: Methods: From 2001 to 2013,all 195 HBVr patients undergoing immunosuppressive therapy in Southwest Hospital were included in this retrospective study.