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目的:检测并分析儿童常年性变应性鼻炎患者的特异性过敏原,探讨其在临床诊断上的意义。方法:采用免疫印迹法体外半定量检测患者14类常见过敏原特异性IgE抗体并分析阳性和强度的分布情况。结果:201例儿童常年性鼻炎患者中173例患者至少对一种以上的过敏原呈阳性反应,阳性率86.1%,有134例患者总IgE大于200IU/ml。在检测的14类常见过敏原中,户尘螨的阳性率最高,为67.7%。结论:血清特异性IgE检测可用于寻找相变应原,为儿童常年性变应性鼻炎患者的预防、诊断及治疗提供重要依据。
OBJECTIVE: To detect and analyze specific allergens in children with perennial allergic rhinitis, and to explore its clinical significance. Methods: 14 kinds of common allergen-specific IgE antibodies were semi-quantitatively detected by Western blotting in vitro and the positive and intensity distributions were analyzed. Results: Of the 201 children with perennial rhinitis, 173 patients were positive for at least one allergen, with a positive rate of 86.1%. The total IgE of 134 patients was more than 200 IU / ml. In the detection of 14 kinds of common allergens, the highest positive rate of house dust mites, 67.7%. Conclusion: Serum-specific IgE test can be used to find the phase response allergen, which provides an important basis for the prevention, diagnosis and treatment of children with perennial allergic rhinitis.