Effects of Mechanical Stress in Normal Fibroblast Activation and Cancer Associated Fibroblast Genesi

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  The significant effects of tumor microenvironment in tumor progression and metastasis have been widely recognized.Cancer associated fibroblasts,one major component in the tumor microenvironment,have been shown to play critical roles in various tumor-stroma interactions.However,to date,the genesis of cancer associated fibroblasts has not been fully understood.
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