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  5. Exercise-induced MIF-regulated AMPK-autophagy cascade attenustes ischemic intolerance of the senesce

Exercise-induced MIF-regulated AMPK-autophagy cascade attenustes ischemic intolerance of the senesce

来源 :International Conference for Physiological Sciences 2012(201 | 被引量 : 0次 | 上传用户：uuu_uuu
【摘 要】
：
Exercise improves myocardial tolerance to ischenfia/reperfusion (I/R) injury in ageing heart although the underlying mechanisms remain unclear.Here, we report that swimming training modulation of macr
【作 者】
：
Lu Yu Yue Yin Yueming Wang Ji Li Heng Ma 
【机 构】
：
Department of Pathology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China
【出 处】
：
International Conference for Physiological Sciences 2012(201
【发表日期】
：
2012年8期
【关键词】
：
ageing exercise AMPK autophagy 
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　　Exercise improves myocardial tolerance to ischenfia/reperfusion (I/R) injury in ageing heart although the underlying mechanisms remain unclear.Here, we report that swimming training modulation of macrophage migration inhibitory factor (MIF)-AMPK dependent autophagy relieves ischemic susceptibility in aged heart.Young (4 months) and aged (22 months) mice maintained 10-week free-loading exercise training (swimming 1 h/d,5 days/week).Exercise training significantly improve the agieng myocarium autophagy.As thus, exercise training improved the toler.a.nce of aged hearts to I/R injury as evidenced by reduced infarct size and cardiomyocytes damage, ameliorated the recovery of LV function after ischemia as well as improved cardiomyocyte contractile function under hypoxic condition.Exercise training also restores the energy in response to I/R an d cardiomyocyte mitochondrial membrane potential (MMP).
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