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Kopsinine and related alkaloids are attractive synthetic targets because of their structural complexity and biological activities.1 An organocatalytic Michael addition/aza-Michael addition/cyclization cascade sequence has been developed for the asymmetric preparation of tetracyclic spiroindolines from 2,3-disubstituted indoles and propargyl aldehyde in moderate to good yields and good to excellent enantioselectivities.The synthetic value of these advanced structures has been demonstrated by the synthesis of kopsinine and related alkaloids.Key steps for concise synthesis of these alkaloids included efficient asymmetric construction of tetracyclic spiroindolines bearing a dienamino ester moiety and organocatalyzed nucleophilic addition of dienamino ester to acrolein.