【摘 要】
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High throughput, combinatorial approaches have revolutionized small molecule drug discovery.Here we describe our work on high throughput methods for develop
【出 处】
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The 3rd Canton Nucleic Acids Forum(第三届广州核酸国际论坛)
论文部分内容阅读
High throughput, combinatorial approaches have revolutionized small molecule drug discovery.Here we describe our work on high throughput methods for developing and characterizing RNA delivery and gene editing systems.Libraries of degradable polymers and lipid-like materials have been synthesized, formulated and screened for their ability to delivery RNA, both in vitro and in vivo.A number of delivery formulations have been developed with in vivo efficacy, and show potential therapeutic application for the treatment of genetic disease, viral infection, and cancer.
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