Upregulation of cystathionine β-synthetase by toll-like receptor 4 activation contributes to viscera

• 作 者: 徐广银;袁波;胡淑芬;朱宏岩;周友浪;张弘弘;
• 机 构: 苏州大学神经科学研究所,苏州 215123
• 出 处: 中国生理学会第24届全国会员代表大会暨生理学学术大会
• 发表日期: 2014年期

　　Background:Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and bloating in association with altered bowel movements.A growing body of evidence points to a key role for toll-like receptor 4 (TLR4) and endogenous hydrogen sulfide (H2S) producing enzyme Cystathionine β-Synthetase (CBS) under chronic pain conditions.