【摘 要】
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Although therapeutic vaccines have emerged as a promising strategy for cancer immunotherapy,their therapeutic efficacy is often dampened by tumor-associated
【机 构】
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Key Lab of Health Informatics of Chinese Academy of Sciences,Guangdong Key Laboratory of Nanomedicin
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
Although therapeutic vaccines have emerged as a promising strategy for cancer immunotherapy,their therapeutic efficacy is often dampened by tumor-associated dendritic cell (TADC) dysfunction,which can be due to the hyperactivity of Signal transducer and activator of transcription 3 (STAT3),an immunosuppressive gene.We previously reported that poly(ethylene glycol)-b-poly(L-lysine)-bpoly(L-leucine) (PEG-PLL-PLLeu) polypeptide micelle-encapsulated Poly I:C (PMP),a TLR3 agonist,was a potent vaccine delivery system to enhance anti-tumor immune responses.In the present study,STAT3 siRNA was co-encapsulated with OVA antigen by PMP to generate PMP/OVA/siRNA in order to overcome TADC dysfunction and further enhance anti-cancer efficacy of vaccines (Scheme 1).The results showed that PMP/OVA/siRNA not only simultaneously facilitated the uptake of OVA and siRNA by dendritic cells,but also successfully decreased STAT3 expression in TADCs.
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