The Differential Cytotoxicity of Water-soluble Fullerene Derivatives by Improved Nitrene Chemistry

• 作 者: JuanLi[1]Rui.He[2]WeiWeiSang[1]YaNanChang[1]GengmeiXing[1]
• 机 构: CAS Key Laboratory for Biomedical Effects of Nanomaterial & Nanosafety,Institute of High Energy Phys
• 出 处: 中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
• 发表日期: 2014年期

　　Water-solublefullerenes,C60[N(CH2)2OH]12,C60[N(CH2)2NH2]10,and C60[N(CH2)2COOH]10,were synthesized by improved nitrene chemistry[1],which C60 was reacted with azide small molecules(N3(CH2)2OH,N3(CH2)2NH2 and N3(CH2)2COOH).The three products were familiar with the size excepted the surface charge character.The cytotoxicity of the water-soluble fullerene species is a sensitive function of surface derivatization; in three different human cell lines(including MDA,HeLa and MCF-7),the median lethal dose of fullerene changed over 3 orders of magnitude with relatively minor alterations in fullerene structure [2].