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Objective Studies on the framing effect indicate that people tend to make risk-avoidant decisions when the choice is framed (e.g.worded) as a choice between gains, but make risk-seeking decisions when it is framed as a choice between losses.So far, the role of anxiety and/or depression in decision-making under framing situations is unclear.We examined the impact of anxiety and depression on the framing effect with a classical monetary gambling task.Methods Participants were instructed that they would have to select either a "sure" or "gamble" option.In gain frame trials, the sure option was presented as money retained; in loss frame trials, it was presented as money lost.The participants decision-making was coded as the proportion of sure option choices for each condition.Results Anxiety, but not depression, had significant effects on framing-related decision-making.Higher levels of anxiety were correlated with stronger flaming effects; most interestingly, high-anxious subjects were more risk-seeking in the loss frame compared to low-anxious subjects, which conflicts with previous findings that high-anxious people are consistently more risk-avoidant.Conclusion The current findings provide evidences that, in contrast with bipolar/ tripolar theoretical models which suggest that all same-valence emotions produce similar cognitive effects, anxiety and depression induce distinct impacts on decision-making.