Targeting Myc and Myc-binding Proteins for the Treatment of Neuroblastoma and Leukemia

来源 :2016第九届世界癌症大会 | 被引量 : 0次 | 上传用户：lihai3120

【摘要】

：

【作者】

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Belamy B.Cheung

【机构】

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Children's Cancer Institute & University of NSW Australia

【出处】

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2016第九届世界癌症大会

【发表日期】

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2016年7期

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　　Amplification of the MYCN oncogene predicts treatment resistance in childhood neuroblastoma.We used a MYC target gene signature that predicts poor neuroblastoma prognosis to identify the histone chaperone FACT (facilitates chromatin transcription) as a crucial mediator of the MYC signal and a therapeutic target in the disease.

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Targeting Myc and Myc-binding Proteins for the Treatment of Neuroblastoma and Leukemia

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