【摘 要】
：
Purpose: Challenges exist in improving early osseointegration.The present article was to investigate the effect of local delivery system of estrogen-loaded solid lipid nano-particles(SLN)on titaniumna
【机 构】
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Center of Oral Implantology,Guangdong Provincial Stomatological Hospital,Southern Medical University
【出 处】
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2014xi`an Conference of International Society for Maxillofac
论文部分内容阅读
Purpose: Challenges exist in improving early osseointegration.The present article was to investigate the effect of local delivery system of estrogen-loaded solid lipid nano-particles(SLN)on titaniumnanotubes(TNT)surface Methods: Estrogen-loaded SLN were prepared by multiple emulsion-solvent diffusion technique,TNT surfaces fabricated by anodic oxidation was then modified by this local delivery system.An in vitro release experiment was conducted to evaluate the sustained release of estrogen.The particle size and morphology of estrogen-loaded SLN were measured by laser particle size analyzer and transmission electron microscope respectively.The osteoblast-like MG-63 cells were used in present study,cell attachment,spread,proliferation,ALP activity and mineralization assay were performed to assess the early cell response
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