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The interaction of nanoparticles with cell membrane is critical in many applications of nanoparticles such as phototherapy,imaging,and drug/gene delivery.These applications require a well understand the mechanism for the nanoparticle-membrane interactions.In this talk we will summarize our recent dissipative particle dynamics studies on the mechanism of nanoparticle uptake into a cell.We find that physical and chemical properties of nanoparticles,such as nanoparticle shape,stiffness,and especially surface coating,have significant influences on their interaction with cells.We first illustrate the dependence of detailed kinetics for the endocytosis of ligand-coated nanoparticles on nanoparticle shape.