The trifluoromethyl group plays a privileged role in pharmaceuticals,agrochemicals and materials science because of its unique properties,and great efforts have been made to develop reactions for its
A newly developed class of quinoline-based chiral biphosphine ligand,6,6-bis(diphenylphosphino)-5,5-biquinoline(BIQAP)was synthesized via a simple two-step reactions using optically pure BIQOL as star
The azaindole ring system is one of the most valuable units present in many biologically active natural products,functional materials and medicinal chemistry.
Palladium-catalyzed three-component coupling of aryl halide and amine with C1 building block,carbon monoxide,remains an indispensable tool for the construction of α-ketoamide scaffolds that are found
Transition-metal-catalyzed C-H activation is an efficient and straightforward tool for the construction of various heterocyclics from simple substrates,which is generally difficult to obtain by using
Owing to the special properties of fluorine,organofluorine chemistry has made great contributions to the development of biology,medicine and material science.
Penta-substituted 1,4-Dihydropyridines were synthesized through catalytic enantioselective cyclization reactions of β,γ-unsaturated α-ketoesters,arylamines and acetylacetone for the first time.
During the recent years,the transition metal catalyzed direct C-H bond functionalization has become a versatile methodology for the modification of heteroaromatic compounds.