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Background and Purpose: Intracranial arterial stenosis (ICAS) is a common etiology of ischemic stroke in Chinese patients, probably leading to regional hypoperfusion in the brain.The purpose of this study was to investigate the association between ICAS and poststroke depression (PSD) in Chinese patients with ischemic stroke.Methods: Two hundred and seven patients with ischemic stroke were consecutively recruited.Depressive symptoms were assessed in the acute stage and three months after stroke.