Dual-decorated liposomes for tumor targeting drug delivery

• 作 者: TianyueJiang;JianpingZhou;HuixiaLv;
• 机 构: Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,P.R.China
• 出 处: 2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
• 发表日期: 2012年期

　　Dual-decorated liposomes with pH-selective cell penetrating peptides (CPPs) and active tumor targeting hyaluronic acid (HA) were fabricated for targeting anticancer drug delivery.A series of novel synthetic tumor pH-triggered CPPs were screened by comparing tumor cellular uptake efficiency at pH 6.4 with at pH 7.4,and R6H4 (RRRRRRHHHH) rich in arginines and histidines was obtained for the strongest pH-selectivity.To construct R6H4-modified liposomes (R6H4-L),R6H4 with stearyl was anchored into liposomes due to hydrophobic interaction.