RNA二级结构对可变剪接调控机制研究

来源 :第十一次全国基因功能与表观遗传调控学术研讨会 | 被引量 : 0次 | 上传用户：APIer

【摘要】

：

RNA可变剪接的调控对生物细胞分化和发育以及疾病发生等至关重要,但对它的作用机制还缺乏了解.RNA二级结构通过不同的机制影响RNA分子的剪接,但之前关于RNA二级结构对剪接影

【作者】

：

岳媛杨赟潘华伟洪伟玲侯守庆马红茹施杨詹雷雷金勇丰

【机构】

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浙江大学生命科学学院

【出处】

：

第十一次全国基因功能与表观遗传调控学术研讨会

【发表日期】

：

2015年10期

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RNA可变剪接的调控对生物细胞分化和发育以及疾病发生等至关重要,但对它的作用机制还缺乏了解.RNA二级结构通过不同的机制影响RNA分子的剪接,但之前关于RNA二级结构对剪接影响的研究主要集中在RNA二级结构对剪接位点识别的调节上.通过比较基因组分析和分子生物学实验等技术表明内含子顺式元件及其相互作用用来调控RNA前体的互斥剪接,提出了一种几种适用外显子可变剪接调控的机制,并对RNA顺式元件与反式作用因子相互作用进行了深入研究.

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RNA二级结构对可变剪接调控机制研究

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