HAMI 3379, A CysLT2R Antagonist, Dose-And Time-Dependently Attenuates Brain Injury And Inhibits Micr

• 作 者: Q.J.Shi H.Wang Z.X.Liu S.H.Fang X.M.Song Y.B.Lu W.P.Zhang X.Y.Sa H.Z.Ying E.Q.Wei
• 机 构: Department of Pharmacology, School of Medicine, Zhejiang University, 866 Yuhangtang Road, Hangzhou 3
• 出 处: 华东地区第十四届实验动物科学学术交流会
• 发表日期: 2016年11期
• 关键词: HAMI 3379 cysteinyl leukotriene receptor 2 (CysLT2R) antagonist cerebral ischemi

　　Cysteinyl leukotrienes (CysLTs) induce inflammatory responses by activating their receptors,CysLT1R and CysLT2R.We have reported that CysLT2R is involved in neuronal injury,astrocytosis,and microgliosis,and that intracerebroventricular (i.c.v.) injection of the selective CysLT2R antagonist HAMI 3379 protects against acute brain injury after focal cerebral ischemia in rats.In the present study,we clarified features of the protective effect of intraperitoneally-injected HAMI 3379 in rats.