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Objective:Platinum compounds,such as cisplatin,carboplatin,oxaliplatin and nedaplatin,are widely usedin the treatment of a number of solid malignancies.Nedaplatin is a second-generation platinum complex basedon its pronounced anticancer activities against various solid tumors equivalent to that of cisplatin but with lowernephrotoxicity.In this context,we aimed to investigate the potential effect of a combination of the nedaplatinand ABT-737.