AcrB efflux pump inhibitors and their reversal of multidrug resistance activity

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：tmd632

【摘要】

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【作者】

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Liwei Guo Yinhu Wang Shutao Ma

【机构】

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Department of Medicinal Chemistry,Key Laboratory of Chemical Biology(Ministry of Education),School o

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

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2015年3期

【关键词】

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multi-drug resistance AcrB efflux pump inhibitors

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　　The increasing multi-drug resistance has become a major threat to the public health [1].Over-expression of multidrug efflux pumps is one of the major mechanisms of drug resistance in bacteria [2].AcrB,as an essential drug efflux protein,has been identified to play a significant role in mediating drug resistance,therefore efflux pump inhibitors(EPIs)appears to be a promising strategy to restore antibacterial efficiency [3].

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AcrB efflux pump inhibitors and their reversal of multidrug resistance activity

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