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  5. Atorvastatin induces autophagy in mesenchymal stem cells under hypoxia and serum deprivation via ano

Atorvastatin induces autophagy in mesenchymal stem cells under hypoxia and serum deprivation via ano

来源 :第11届中国介入心脏病学大会 | 被引量 : 0次 | 上传用户：liusheng123321
【摘 要】
：
Background Mesenchymal stem cells (MSCs) are one of the optimal candidates for myocardial infarction; however,the survival ratio of implanted cells in the infarcted heart is low.Autophagy is a complex
【作 者】
：
NA Li YANG Yue-jin ZHANG Qian QIAN Hai-yan JIN Chen WANG Hong 
【机 构】
：
State Key Laboratory of Cardiovascular Disease,Fuwai Hospital National Center for Cardiovascular Dis
【出 处】
：
第11届中国介入心脏病学大会
【发表日期】
：
2013年7期
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Background Mesenchymal stem cells (MSCs) are one of the optimal candidates for myocardial infarction; however,the survival ratio of implanted cells in the infarcted heart is low.Autophagy is a complex "self-eating" process and could be utilized for cell survival under stresses.We have previously shown that the cholesterol lowering drug atorvastatin(ATV) could effectively activate autophagy via AMPK/mTOR pathway to enhance MSCs survival during hypoxia and serum deprivation (H/SD).Studies indicated that mitogen-activated protein kinase/extracellular signal-regulated kinase(MEK/ERK1/2) pathway is important in mediating survival signaling.Therefore, we hypothesized that MEK/ERK1/2pathway also participates in ATV induced autophagy in MSCS under H/SD.
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