First synthesis of pyrimido[4,5-b]indol-2-amine derivatives.The isomeric ring system of Meridianins

• 作 者: Wentao Gao Yang Li
• 机 构: Institute of Superfine Chemicals,Bohai University,Jinzhou,121000,China
• 出 处: 中国化学会第30届学术年会
• 发表日期: 2016年期

　　Meridianins(4-(indol-3-yl)pyrimidin-2-amines,Figure 1),isolated from the tunicate Aplidium meridiaum[1] have been deeply studied as potent inhibitors of several protein kinases,and have been recently screened as agents for cancer therapy.