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Many service users with substance abuse are commonly the low academic achievers and unskilled workers.They usually have unstable employment or even worse, long term unemployment.Most of them thus encounter occupational lifestyle dysfunction and manifest as lack of content and maladapted everyday life.They usually possess negative thoughts and no concrete goal for a meaningful life that leading the on-going abuse of substance and alcohol.Literature results revealed that employment had been one of the protective factors against substance abuse.And Occupational Lifestyle Redesign Program (OLSR), which aims at developing happiness-inducing lifestyle in different life domains, had previously been found to be effective in reducing mood problem and promoting mental health.Therefore, as keys of occupational therapy, vocational rehabilitation and lifestyle restructure are vital parts of the treatment programs for people with substance abuse.