PROTEOMICS SCREEN TO REVEAL MOLECULAR CHANGES MEDIATED BY C722G MISSENSE MUTATION IN CHRM2 GENE

• 作 者: Hou Dong Yan Aihua Hu Lin Xu Lin Zhang Ying Chen Jiamei Liu Juan Zhang Hua Wang Zhiyong Zhang Xin Wang Jin Chen Hakon Hakonarson
• 机 构: Heart Failure Center,Department of Cardiology,Capital Medical University,Beijing Chao-yang Hospital,
• 出 处: 第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int
• 发表日期: 2013年2期

Objectives Previously, we reported that a missense mutation (C722G) in the M2-muscarinic acetylcholine receptor (CHRM2) geneis associated with familial dilated cardiomyopathy (DCM).However, the exact molecular mechanisms by the fundamental changes involved in the CHRM2 signalling pathways in patients with the C722G mutation are still not clear.