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Background: To assess the changes of bone mineral density (BMD) in patients with ankylosing spondylitis (AS) by QCT and guide the clinical treatment.Methods: The BMD of lumbar vertebra 1-5 were measured in 60 male patients with AS and 20 healthy male controls by quantitative computed tomography (QCT).Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were determined.