【摘 要】
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The idea, auditory information might be encoded in the spike timing, rather than in neuronal firing rates, has been attracting increasing attention from the 90 s of last century.It remains unclear, ho
【机 构】
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Department of Physiology, Department of bioinformatics, School of Basic Medical Sciences, Southern M
【出 处】
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中国神经科学学会第九届全国学术会议暨第五届会员代表大会
论文部分内容阅读
The idea, auditory information might be encoded in the spike timing, rather than in neuronal firing rates, has been attracting increasing attention from the 90 s of last century.It remains unclear, however, whether or not spike timing might encode the response state of auditory system.Here we investigated the latency characteristics of local auditory evoked potentials (LAEPs) in mice inferior colliculus during pentobarbital induced continuously change of response state of auditory system.After intraperitoneal infusion of sodium pentobarbital, LAEPs evoked by different stimulus intensities were recorded as a dataset every 10 minutes (defined as a recording session).Then the latency from the beginning of sound delivery to the first negative peak (N 1) of each LAEP on all the recording sessions during anesthesia was extracted and plotted as a function of stimulus intensity.For further analysis the data, we employed a double coordinate axis fitting shift algorithm (DCAFSA) basing on Pierons empirical law to calculate the latency shift of each latency-intensity function, which were plotted as a function of recording session.Our result showed that the latency shift prolonged to a plateau and then shortened smoothly with recording session after the pentobarbital injection.Moreover, similar phenomenon was more clearly observed across populations of recording sites and animals.By abdominal administration, the absorption and metabolism of anesthetics would result in a reversible time-effect relationship, which will change the response state of auditory system in parallel.Thus, the latency shift of LAEPs is a potential index to quantitatively encode the auditory response state.
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