【摘 要】
：
目的 探讨我国GERD患者的BMI对其胃食管反流的影响.方法 共纳入114例GERD患者,年龄为20～＜70岁,具有典型烧心、反流症状,病程＞3个月,检查前停用影响消化道动力及胃液pH值的药物≥7d.记录受试者的身高和体质量,采用Ohmega阻抗-pH联合监测系统行24 h监测.各项指标均在正常范围内判定为生理性反流,任何一项指标的检查值大于正常值上限则判定为病理性反流,对具有病理性反流的GERD
【机 构】
：
710004 西安交通大学第二附属医院消化内科 包头医学院第二附属医院消化内科
【出 处】
：
The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议)
论文部分内容阅读
目的 探讨我国GERD患者的BMI对其胃食管反流的影响.方法 共纳入114例GERD患者,年龄为20～＜70岁,具有典型烧心、反流症状,病程＞3个月,检查前停用影响消化道动力及胃液pH值的药物≥7d.记录受试者的身高和体质量,采用Ohmega阻抗-pH联合监测系统行24 h监测.各项指标均在正常范围内判定为生理性反流,任何一项指标的检查值大于正常值上限则判定为病理性反流,对具有病理性反流的GERD患者的资料进行统计学分析.114例GERD患者中,104例具有病理性反流,根据WHO亚太地区肥胖诊断标准,将其分成偏瘦组13例(BMI＜18.5 kg/m2)、正常体质量组46例(BMI为18.5～＜23.0 kg/m2)、偏胖组24例(BMI为23.0～＜25.0 kg/m2)、肥胖组21例(BMI≥25.0 kg/m2),无重度肥胖患者.应用SPSS 17.0统计软件,行组间DeMeester评分、pH＜4反流时间百分比、反流周期数、长反流周期数、最长反流时间、食团清除时间、直立位酸反流、直立位液体反流、仰卧位液体反流等的指标分析.结果 偏瘦组、正常体质量组、偏胖组和肥胖组4组患者的性别和年龄组成差异均元统计学意义(P均＞0.05).偏瘦组患者的各项指标与正常体质量组的比较差异均无统计学意义(P均＞0.05),但其中偏瘦组的DeMeester评分、pH＜4反流时间百分比、长反流周期数、最长反流时间和食团清除时间均较高.偏胖组患者的各项指标均比正常体质量组高,除了仰卧位液体反流,其余指标差异均无统计学意义(P均＞0.05).肥胖组的DeMeester评分、pH＜4反流时间百分比、反流周期数、最长反流时间、直立位酸反流和直立位液体反流的监测值均明显高于正常体质量组的,差异均有统计学意义(P均＜0.05).肥胖组的DeMeester评分、pH＜4反流时间百分比、反流周期数、长反流周期数和最长反流时间的监测值均高于偏胖组的,但差异均无统计学意义(P均＞0.05).结论 肥胖(BMI≥25.0 kg/m2)与我国GERD患者的胃食管反流具有相关性,偏瘦和偏胖也有促进反流的倾向.肥胖的GERD患者,需大幅度降低BMI才有助于改善其反流症状.此外,BMI测量简便、客观,可作为肥胖的指标用于分析肥胖对GERD的影响.
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