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目的:对A型和AB型婴儿红细胞进行A1抗原血清学检测,以了解其红细胞上A1抗原的表达情况。方法:采用常规试管法及4℃冰箱1h增强反应对A型和AB型婴儿红细胞进行A1抗原检测和确认。结果:155例A(AB)型婴儿中检测出A1抗原121例(78.06%),其中28d以内的新生儿3例(8.57%),29d以上118例(98.33%),两组比较差异有统计学意义(P<0.01)。A型婴儿127例,检出A1抗原105例(82.68%);AB型婴儿28例,A1抗原检出19例(67.86%),两组比较差异有统计学意义(P<0.05)。结论:A型与AB型婴儿红细胞上的A1抗原在21~28d开始表达;因此新生儿在0~28d检测A1抗原是无意义的,要在1个月以后做4℃增强反应才有意义;同时同龄AB型婴儿的A1抗原表达强度明显弱于A型婴儿。
Objective: To test the A1 antigen serotypes of type A and type AB infant erythrocytes to understand the expression of A1 antigen on erythrocytes. Methods: A1 antigen was detected and confirmed in type A and AB infants by conventional test tube method and enhanced reaction at 4 ℃ for 1 h. Results: Among the 155 A (AB) infants, 121 cases (78.06%) were detected with A1 antigen, including 3 neonates within 28 days (8.57%) and 118 patients (98.33%) over 29 days. There were statistically significant differences between the two groups Significance (P <0.01). A type of infants in 127 cases, A1 antigen was detected in 105 cases (82.68%); 28 cases of AB infants, A1 antigen was detected in 19 cases (67.86%), the difference between the two groups was statistically significant (P <0.05). CONCLUSIONS: The A1 antigen on type A and type AB infant erythrocytes expresses from 21 to 28 days. Therefore, it is meaningless for the newborn to detect the A1 antigen from 0 to 28 days. It is meaningful to do the enhanced reaction at 4 ℃ after 1 month. At the same age AB-type infants A1 expression intensity was significantly weaker than the A-type infants.