Immune activation contributes to CD4+ T cells depletion in gastrointestinal system of SIV infected m

• 作 者: Jin-BiaoLiu[1]Jie-LiangLi[2]Qian-HaoXiao[1]GeGao[1]LiZhou[1]MingSang[1]KeZhuang[1]XuWang[3]Wen-ZheHo[2]
• 机 构: ABSL-3 Laboratory at the Center for Animal Experiment,State Key Laboratory of Virology,Wuhan Univers
• 出 处: 第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会
• 发表日期: 2015年期

　　Introduction: HIV-induced chronic immune activation contributes to CD4+ T ceils depletion and drives progression to HIV disease.However,the direct causal link between chronic immune activation and CD4+ T cells depletion has not been well established.Objectives: To examine whether immune activation contributes to CD4+ T cells depletion in gastrointestinal system(GI)from SIV-infected macaques.